Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing

Degradation of mRNA by RNA interference is one of the most powerful and specific mechanisms for gene silencing. However, insufficient cellular uptake and poor stability have limited its usefulness. Here, we report efficient delivery of siRNA via the use of biodegradable nanoparticles (NPs) made from...

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Detalles Bibliográficos
Autores principales: Du, Jing, Sun, Ying, Shi, Qiu-Sheng, Liu, Pei-Feng, Zhu, Ming-Jie, Wang, Chun-Hui, Du, Lian-Fang, Duan, You-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269702/
https://www.ncbi.nlm.nih.gov/pubmed/22312268
http://dx.doi.org/10.3390/ijms13010516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269702/
https://www.ncbi.nlm.nih.gov/pubmed/22312268
http://dx.doi.org/10.3390/ijms13010516

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