Reduced mRNA Secondary-Structure Stability Near the Start Codon Indicates Functional Genes in Prokaryotes

Several recent studies have found that selection acts on synonymous mutations at the beginning of genes to reduce mRNA secondary-structure stability, presumably to aid in translation initiation. This observation suggests that a metric of relative mRNA secondary-structure stability, Z(ΔG), could be u...

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Detalles Bibliográficos
Autores principales: Keller, Thomas E., Mis, S. David, Jia, Kevin E., Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269970/
https://www.ncbi.nlm.nih.gov/pubmed/22138151
http://dx.doi.org/10.1093/gbe/evr129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269970/
https://www.ncbi.nlm.nih.gov/pubmed/22138151
http://dx.doi.org/10.1093/gbe/evr129

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