Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte

Inotropy and lusitropy in the ventricular myocyte can be efficiently induced by activation of β1-, but not β2-, adrenoceptors (ARs). Compartmentation of β2-AR-derived cAMP-dependent signalling underlies this functional discrepancy. Here we investigate the mechanism by which caveolae (specialised sar...

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Detalles Bibliográficos
Autores principales: MacDougall, David A., Agarwal, Shailesh R., Stopford, Elizabeth A., Chu, Hongjin, Collins, Jennifer A., Longster, Anna L., Colyer, John, Harvey, Robert D., Calaghan, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270222/
https://www.ncbi.nlm.nih.gov/pubmed/21740911
http://dx.doi.org/10.1016/j.yjmcc.2011.06.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270222/
https://www.ncbi.nlm.nih.gov/pubmed/21740911
http://dx.doi.org/10.1016/j.yjmcc.2011.06.014

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