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Drug-mediated inhibition of Fli-1 for the treatment of leukemia

The Ets transcription factor, Fli-1 is activated in murine erythroleukemia and overexpressed in various human malignancies including Ewing's sarcoma, induced by the oncogenic fusion protein EWS/Fli-1. Recent studies by our group and others have demonstrated that Fli-1 plays a key role in tumori...

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Detalles Bibliográficos
Autores principales: Li, Y-J, Zhao, X, Vecchiarelli-Federico, L M, Li, Y, Datti, A, Cheng, Y, Ben-David, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270256/
https://www.ncbi.nlm.nih.gov/pubmed/22829238
http://dx.doi.org/10.1038/bcj.2011.52