Role of the promyelocytic leukaemia protein in cell death regulation

The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffol...

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Detalles Bibliográficos
Autores principales: Salomoni, P, Dvorkina, M, Michod, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270264/
https://www.ncbi.nlm.nih.gov/pubmed/22237204
http://dx.doi.org/10.1038/cddis.2011.122
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author Salomoni, P
Dvorkina, M
Michod, D
author_facet Salomoni, P
Dvorkina, M
Michod, D
author_sort Salomoni, P
collection PubMed
description The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation.
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spelling pubmed-32702642012-02-02 Role of the promyelocytic leukaemia protein in cell death regulation Salomoni, P Dvorkina, M Michod, D Cell Death Dis Review The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation. Nature Publishing Group 2012-01 2012-01-12 /pmc/articles/PMC3270264/ /pubmed/22237204 http://dx.doi.org/10.1038/cddis.2011.122 Text en Copyright © 2012 Macmillan Publishers Limited
spellingShingle Review
Salomoni, P
Dvorkina, M
Michod, D
Role of the promyelocytic leukaemia protein in cell death regulation
title Role of the promyelocytic leukaemia protein in cell death regulation
title_full Role of the promyelocytic leukaemia protein in cell death regulation
title_fullStr Role of the promyelocytic leukaemia protein in cell death regulation
title_full_unstemmed Role of the promyelocytic leukaemia protein in cell death regulation
title_short Role of the promyelocytic leukaemia protein in cell death regulation
title_sort role of the promyelocytic leukaemia protein in cell death regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270264/
https://www.ncbi.nlm.nih.gov/pubmed/22237204
http://dx.doi.org/10.1038/cddis.2011.122
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