Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair

Uracil DNA glycosylase (UDG) specifically removes uracil bases from DNA, and its repair activity determines the sensitivity of the cell to anticancer agents that are capable of introducing uracil into DNA. In the present study, the participation of UDG in the response to pemetrexed-induced incorpora...

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Detalles Bibliográficos
Autores principales: Bulgar, A D, Weeks, L D, Miao, Y, Yang, S, Xu, Y, Guo, C, Markowitz, S, Oleinick, N, Gerson, S L, Liu, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270269/
https://www.ncbi.nlm.nih.gov/pubmed/22237209
http://dx.doi.org/10.1038/cddis.2011.135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270269/
https://www.ncbi.nlm.nih.gov/pubmed/22237209
http://dx.doi.org/10.1038/cddis.2011.135

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