Accumulation of Vesicle-Associated Human Tau in Distal Dendrites Drives Degeneration and Tau Secretion in an In Situ Cellular Tauopathy Model

We used a nontransgenic cellular tauopathy model in which individual giant neurons in the lamprey CNS (ABCs) overexpress human tau isoforms cell autonomously to characterize the still poorly understood consequences of disease-associated tau processing in situ. In this model, tau colocalizes with end...

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Detalles Bibliográficos
Autores principales: Lee, Sangmook, Kim, WonHee, Li, Zhihan, Hall, Garth F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270555/
https://www.ncbi.nlm.nih.gov/pubmed/22315694
http://dx.doi.org/10.1155/2012/172837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270555/
https://www.ncbi.nlm.nih.gov/pubmed/22315694
http://dx.doi.org/10.1155/2012/172837

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