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The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals
The role of rare genetic variation in the etiology of complex disease remains unclear. However, the development of next-generation sequencing technologies offers the experimental opportunity to address this question. Several novel statistical methodologies have been recently proposed to assess the c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271058/ https://www.ncbi.nlm.nih.gov/pubmed/22319458 http://dx.doi.org/10.1371/journal.pgen.1002496 |