Gu-4 Suppresses Affinity and Avidity Modulation of CD11b and Improves the Outcome of Mice with Endotoxemia and Sepsis

BACKGROUND: Systemic leukocyte activation and disseminated leukocyte adhesion will impair the microcirculation and cause severe decrements in tissue perfusion and organ function in the process of severe sepsis. Gu-4, a lactosyl derivative, could selectively target CD11b to exert therapeutic effect i...

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Detalles Bibliográficos
Autores principales: Yan, TingTing, Li, Qing, Zhou, HuiTing, Zhao, YueTao, Yu, ShuQin, Xu, GuangLin, Yin, ZhiMin, Li, ZhongJun, Zhao, ZhiHui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271073/
https://www.ncbi.nlm.nih.gov/pubmed/22319560
http://dx.doi.org/10.1371/journal.pone.0030110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271073/
https://www.ncbi.nlm.nih.gov/pubmed/22319560
http://dx.doi.org/10.1371/journal.pone.0030110

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