Cargando…

InsR/FoxO1 Signaling Curtails Hypothalamic POMC Neuron Number

Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited. To investigate the role of InsR/FoxO1 signaling in the development and maintenance of these circuits, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Plum, Leona, Lin, Hua V., Aizawa, Kumiko S., Liu, Yitian, Accili, Domenico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271107/ https://www.ncbi.nlm.nih.gov/pubmed/22319636 http://dx.doi.org/10.1371/journal.pone.0031487

Ejemplares similares

The Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro–opiomelanocortin Neurons with Regulation of Food Intake
por: Plum, Leona, et al.
Publicado: (2009)

Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre–Expressing Neurons
por: Ren, Hongxia, et al.
Publicado: (2013)

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
por: Lin, Hua V., et al.
Publicado: (2010)

Preserved Energy Balance in Mice Lacking FoxO1 in Neurons of Nkx2.1 Lineage Reveals Functional Heterogeneity of FoxO1 Signaling Within the Hypothalamus
por: Heinrich, Garrett, et al.
Publicado: (2014)

Lactate activates hypothalamic POMC neurons by intercellular signaling
por: Órdenes, P., et al.
Publicado: (2021)

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice
por: Susanti, Vina Yanti, et al.
Publicado: (2014)

Metformin ameliorates olanzapine-induced disturbances in POMC neuron number, axonal projection, and hypothalamic leptin resistance
por: Kim, Jaedeok, et al.
Publicado: (2022)

Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons
por: Hill, Jennifer W.
Publicado: (2010)

Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats
por: Zhou, Shengnan, et al.
Publicado: (2022)

OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
por: Gahlot, Surbhi, et al.
Publicado: (2020)

Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
por: Xia, Pengyan, et al.
Publicado: (2015)

Igf1R/InsR function is required for axon extension and corpus callosum formation
por: Jin, Jing, et al.
Publicado: (2019)

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons
por: Hu, Jun, et al.
Publicado: (2014)

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring
por: Silva, Jose P., et al.
Publicado: (2016)

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
por: Varela, Luis, et al.
Publicado: (2017)

Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake
por: Ha, Go Eun, et al.
Publicado: (2021)

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner
por: Pajvani, Utpal B., et al.
Publicado: (2011)

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity
por: Gamber, Kevin M., et al.
Publicado: (2012)

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice
por: Mercer, Rebecca E., et al.
Publicado: (2013)

Correction: Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes
por: Tsunekawa, Shin, et al.
Publicado: (2011)

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity
por: Yu, Hui, et al.
Publicado: (2020)

A Mutant Allele Encoding DNA Binding–Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism
por: Cook, Joshua R., et al.
Publicado: (2015)

Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice
por: Ishida, Emi, et al.
Publicado: (2017)

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
por: Sousa-Ferreira, Lígia, et al.
Publicado: (2011)

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
por: Burke, Luke K., et al.
Publicado: (2016)

Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling
por: Yuan, Feixiang, et al.
Publicado: (2020)

Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin
por: Perissinotti, Paula P., et al.
Publicado: (2021)

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes
por: Yu, Hui, et al.
Publicado: (2022)

Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits
por: Fang, Xing, et al.
Publicado: (2022)

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)
por: Meur, Gargi, et al.
Publicado: (2011)

Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function
por: Kuo, Taiyi, et al.
Publicado: (2021)

Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
por: Souza, Gabriela F. P., et al.
Publicado: (2016)

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2
por: Zanesco, Ariane Maria, et al.
Publicado: (2022)

Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1
por: Li, Xiu-Dan, et al.
Publicado: (2021)

Integrated Control Of Hepatic Lipogenesis Vs. Glucose Production Requires FoxO Transcription Factors
por: Haeusler, Rebecca A., et al.
Publicado: (2014)

Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
por: Ren, Hongxia, et al.
Publicado: (2015)

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales
por: Mandelblat-Cerf, Yael, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gf35jku5ur8u6df0qtoub0lfjs