DNA breaks and chromosome pulverization from errors in mitosis

Whether whole-chromosome aneuploidy promotes tumorigenesis has been controversial, in large part because of the paucity of insight into underlying mechanisms. Here we identify a mechanism by which mitotic chromosome segregation errors generate DNA breaks via the formation of structures called micron...

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Detalles Bibliográficos
Autores principales: Crasta, Karen, Ganem, Neil J., Dagher, Regina, Lantermann, Alexandra B., Ivanova, Elena V., Pan, Yunfeng, Nezi, Luigi, Protopopov, Alexei, Chowdhury, Dipanjan, Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271137/
https://www.ncbi.nlm.nih.gov/pubmed/22258507
http://dx.doi.org/10.1038/nature10802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271137/
https://www.ncbi.nlm.nih.gov/pubmed/22258507
http://dx.doi.org/10.1038/nature10802

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