Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor

The cell of origin of tumors and the the factors determining the cell of origin remain unclear. In this study, a mouse model of precursor-B acute lymphoblastic leukemia/lymphoma (pre-B ALL/LBL) was established by retroviral transduction of Myc genes (N-Myc or c-Myc) into mouse bone marrow cells. Hem...

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Detalles Bibliográficos
Autores principales: Sugihara, Eiji, Shimizu, Takatsune, Kojima, Kensuke, Onishi, Nobuyuki, Kai, Kazuharu, Ishizawa, Jo, Nagata, Keiko, Hashimoto, Norisato, Honda, Hiroaki, Kanno, Masamoto, Miwa, Masanao, Okada, Seiji, Andreeff, Michael, Saya, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271180/
https://www.ncbi.nlm.nih.gov/pubmed/21986948
http://dx.doi.org/10.1038/onc.2011.462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271180/
https://www.ncbi.nlm.nih.gov/pubmed/21986948
http://dx.doi.org/10.1038/onc.2011.462

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