Cargando…

Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle

Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal muscle. In differentiated myofibres, we observed that Wnt7a binding to Fzd7 directly activates the Akt/mTOR growth p...

Descripción completa

Detalles Bibliográficos
Autores principales: von Maltzahn, Julia, Bentzinger, C. Florian, Rudnicki, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271181/
https://www.ncbi.nlm.nih.gov/pubmed/22179044
http://dx.doi.org/10.1038/ncb2404
_version_ 1782222661970034688
author von Maltzahn, Julia
Bentzinger, C. Florian
Rudnicki, Michael A
author_facet von Maltzahn, Julia
Bentzinger, C. Florian
Rudnicki, Michael A
author_sort von Maltzahn, Julia
collection PubMed
description Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal muscle. In differentiated myofibres, we observed that Wnt7a binding to Fzd7 directly activates the Akt/mTOR growth pathway thereby inducing myofibre hypertrophy. Notably, the Fzd7 receptor complex was associated with Gαs and PI3kinase and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. Wnt7a/Fzd7 activation of this pathway was completely independent of IGF-receptor activation. Together, these experiments demonstrate that Wnt7a/Fzd7 activates distinct pathways at different developmental stages during myogenic lineage progression, and together identify a novel non-canonical anabolic signalling pathway for Wnt7a and its receptor Fzd7 in skeletal muscle.
format Online
Article
Text
id pubmed-3271181
institution National Center for Biotechnology Information
language English
publishDate 2011
record_format MEDLINE/PubMed
spelling pubmed-32711812012-08-01 Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle von Maltzahn, Julia Bentzinger, C. Florian Rudnicki, Michael A Nat Cell Biol Article Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal muscle. In differentiated myofibres, we observed that Wnt7a binding to Fzd7 directly activates the Akt/mTOR growth pathway thereby inducing myofibre hypertrophy. Notably, the Fzd7 receptor complex was associated with Gαs and PI3kinase and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. Wnt7a/Fzd7 activation of this pathway was completely independent of IGF-receptor activation. Together, these experiments demonstrate that Wnt7a/Fzd7 activates distinct pathways at different developmental stages during myogenic lineage progression, and together identify a novel non-canonical anabolic signalling pathway for Wnt7a and its receptor Fzd7 in skeletal muscle. 2011-12-18 /pmc/articles/PMC3271181/ /pubmed/22179044 http://dx.doi.org/10.1038/ncb2404 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
von Maltzahn, Julia
Bentzinger, C. Florian
Rudnicki, Michael A
Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle
title Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle
title_full Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle
title_fullStr Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle
title_full_unstemmed Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle
title_short Wnt7a/Fzd7 Signalling Directly Activates the Akt/mTOR Anabolic Growth Pathway in Skeletal Muscle
title_sort wnt7a/fzd7 signalling directly activates the akt/mtor anabolic growth pathway in skeletal muscle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271181/
https://www.ncbi.nlm.nih.gov/pubmed/22179044
http://dx.doi.org/10.1038/ncb2404
work_keys_str_mv AT vonmaltzahnjulia wnt7afzd7signallingdirectlyactivatestheaktmtoranabolicgrowthpathwayinskeletalmuscle
AT bentzingercflorian wnt7afzd7signallingdirectlyactivatestheaktmtoranabolicgrowthpathwayinskeletalmuscle
AT rudnickimichaela wnt7afzd7signallingdirectlyactivatestheaktmtoranabolicgrowthpathwayinskeletalmuscle