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An unanticipated architecture of the 750 kD holoenzyme of 3-methylcrotonyl-CoA carboxylase
3-methylcrotonyl-CoA carboxylase (MCC), a member of the biotin-dependent carboxylase superfamily, is essential for the metabolism of leucine, and deficient mutations in this enzyme are linked to methylcrotonylglycinuria (MCG) and other serious diseases in humans (1–8). MCC has strong sequence conser...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271731/ https://www.ncbi.nlm.nih.gov/pubmed/22158123 http://dx.doi.org/10.1038/nature10691 |