Cargando…

Klotho Lacks a Vitamin D Independent Physiological Role in Glucose Homeostasis, Bone Turnover, and Steady-State PTH Secretion In Vivo

Apart from its function as co-receptor for fibroblast growth factor-23 (FGF23), Klotho is thought to regulate insulin signaling, intracellular oxidative stress, and parathyroid hormone (PTH) secretion in an FGF23 independent fashion. Here, we crossed Klotho deficient (Kl(−/−)) mice with vitamin D re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anour, René, Andrukhova, Olena, Ritter, Eva, Zeitz, Ute, Erben, Reinhold G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272012/ https://www.ncbi.nlm.nih.gov/pubmed/22319626 http://dx.doi.org/10.1371/journal.pone.0031376

Ejemplares similares

Lack of vitamin D signalling per se does not aggravate cardiac functional impairment induced by myocardial infarction in mice
por: Ford, Kristopher, et al.
Publicado: (2018)

Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload
por: Slavic, Svetlana, et al.
Publicado: (2017)

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
por: Andrukhova, Olena, et al.
Publicado: (2012)

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho (−/−) Mice
por: Yuan, Quan, et al.
Publicado: (2012)

α-Klotho's effects on mineral homeostasis are fibroblast growth factor-23 dependent
por: Erben, Reinhold G.
Publicado: (2018)

FGF23 regulates renal sodium handling and blood pressure
por: Andrukhova, Olena, et al.
Publicado: (2014)

Augmented Fibroblast Growth Factor-23 Secretion in Bone Locally Contributes to Impaired Bone Mineralization in Chronic Kidney Disease in Mice
por: Andrukhova, Olena, et al.
Publicado: (2018)

Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp Mice
por: Murali, Sathish K., et al.
Publicado: (2016)

Aldosterone Is Positively Associated With Circulating FGF23 Levels in Chronic Kidney Disease Across Four Species, and May Drive FGF23 Secretion Directly
por: Radloff, Judith, et al.
Publicado: (2021)

FGF23 promotes renal calcium reabsorption through the TRPV5 channel
por: Andrukhova, Olena, et al.
Publicado: (2014)

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond
por: Portales-Castillo, Ignacio, et al.
Publicado: (2022)

Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor‐23
por: Andrukhova, Olena, et al.
Publicado: (2015)

Editorial: Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
por: Erben, Reinhold G.
Publicado: (2019)

Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
por: Streicher, Carmen, et al.
Publicado: (2017)

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion
por: Olauson, Hannes, et al.
Publicado: (2013)

The bone is the major source of high circulating intact fibroblast growth factor-23 in acute murine polymicrobial sepsis induced by cecum ligation puncture
por: Bayer, Jessica, et al.
Publicado: (2021)

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
por: Ghazavi, Farzaneh, et al.
Publicado: (2022)

Determinants of Low Bone Turnover in Type 2 Diabetes-the Role of PTH
por: Vavanikunnel, Janina, et al.
Publicado: (2022)

Control of PTH secretion by the TRPC1 ion channel
por: Onopiuk, Marta, et al.
Publicado: (2020)

Low Bone Turnover and Low BMD in Down Syndrome: Effect of Intermittent PTH Treatment
por: Fowler, Tristan W., et al.
Publicado: (2012)

FGF23 and Vitamin D Metabolism
por: Latic, Nejla, et al.
Publicado: (2021)

Ectopic Intact PTH Secretion Causing Humoral Hypercalcemia of Malignancy
por: Rauf, Mohammad Talha, et al.
Publicado: (2021)

Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice
por: Moschinger, Michael, et al.
Publicado: (2019)

Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
por: Kim, Hee-Kwon, et al.
Publicado: (2016)

Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure
por: Latic, Nejla, et al.
Publicado: (2020)

Paracrine Kynurenic Pathway Activation in the Bone of Young Uremic Rats Can Antagonize Anabolic Effects of PTH on Bone Turnover and Strength through the Disruption of PTH-Dependent Molecular Signaling
por: Pawlak, Krystyna, et al.
Publicado: (2021)

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
por: Fu, Xuekun, et al.
Publicado: (2020)

Effects of parathyroid hormone rhPTH(1–84) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study
por: Clarke, Bart L., et al.
Publicado: (2016)

Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis
por: Chuchana, Paul, et al.
Publicado: (2018)

Selective inhibition of receptor activator of NF-κB ligand (RANKL) in hematopoietic cells improves outcome after experimental myocardial infarction
por: Slavic, Svetlana, et al.
Publicado: (2018)

An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor
por: Uchida, Kosuke, et al.
Publicado: (2017)

FGF-23, Klotho and Vitamin D Levels in Scleroderma
por: AHMADI, Ravan, et al.
Publicado: (2017)

Klotho and vitamin D in multiple sclerosis: an Italian study
por: Scazzone, Concetta, et al.
Publicado: (2019)

Discovery of α-Klotho unveiled new insights into calcium and phosphate homeostasis
por: Nabeshima, Yo-ichi
Publicado: (2009)

Calciphylaxis associated with chronic kidney disease and low bone turnover: management with recombinant human PTH-(1–34)
por: Elder, Grahame, et al.
Publicado: (2008)

Interaction of Vitamin D with Peptide Hormones with Emphasis on Parathyroid Hormone, FGF23, and the Renin-Angiotensin-Aldosterone System
por: Latic, Nejla, et al.
Publicado: (2022)

Protocol for intervention-free quantification of protein turnover rate by steady-state modeling
por: Marcotti, Stefania, et al.
Publicado: (2021)

SAT211 PTH-secreting Endometrial Carcinoma: A Rare Cause of Hypercalcemia
por: Fanous, Ereeny, et al.
Publicado: (2023)

Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)
por: Noda, Hiroshi, et al.
Publicado: (2020)

Case Report: Inactivating PTH/PTHrP Signaling Disorder Type 1 Presenting With PTH Resistance
por: Demaret, Tanguy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1panc8t3esevmhc03edkik6ahh