Experimental conditions can obscure the second high-affinity site in LeuT

Neurotransmitter:Na(+) Symporters (NSSs), the targets of antidepressants and psychostimulants, recapture neurotransmitters from the synapse in a Na(+)-dependent symport mechanism. The crystal structure of the NSS homologue LeuT from Aquifex aeolicus revealed one leucine substrate in an occluded cent...

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Detalles Bibliográficos
Autores principales: Quick, Matthias, Shi, Lei, Zehnpfennig, Britta, Weinstein, Harel, Javitch, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272158/
https://www.ncbi.nlm.nih.gov/pubmed/22245968
http://dx.doi.org/10.1038/nsmb.2197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272158/
https://www.ncbi.nlm.nih.gov/pubmed/22245968
http://dx.doi.org/10.1038/nsmb.2197

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