THE RAD9-RAD1-HUS1 (9.1.1) COMPLEX INTERACTS WITH WRN AND IS CRUCIAL TO REGULATE ITS RESPONSE TO REPLICATION FORK STALLING

The WRN protein belongs to the RecQ family of DNA helicases and is implicated in replication fork restart, but how its function is regulated remains unknown. We show that WRN interacts with the 9.1.1 complex, one of the central factors of the replication checkpoint. This interaction is mediated by t...

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Detalles Bibliográficos
Autores principales: Pichierri, Pietro, Nicolai, Sara, Cignolo, Luca, Bignami, Margherita, Franchitto, Annapaola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272477/
https://www.ncbi.nlm.nih.gov/pubmed/22002307
http://dx.doi.org/10.1038/onc.2011.468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272477/
https://www.ncbi.nlm.nih.gov/pubmed/22002307
http://dx.doi.org/10.1038/onc.2011.468

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