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THE RAD9-RAD1-HUS1 (9.1.1) COMPLEX INTERACTS WITH WRN AND IS CRUCIAL TO REGULATE ITS RESPONSE TO REPLICATION FORK STALLING
The WRN protein belongs to the RecQ family of DNA helicases and is implicated in replication fork restart, but how its function is regulated remains unknown. We show that WRN interacts with the 9.1.1 complex, one of the central factors of the replication checkpoint. This interaction is mediated by t...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272477/ https://www.ncbi.nlm.nih.gov/pubmed/22002307 http://dx.doi.org/10.1038/onc.2011.468 |