Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex

RAD18, a RING-type ubiquitin ligase (E3) that plays an essential role in post-replication repair, possesses distinct domains named RING, UBZ, SAP and the RAD6-binding domain (R6BD) and forms a dimer. RAD6, an ubiquitin-conjugating enzyme (E2), stably associates with R6BD in the C-terminal portion. I...

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Detalles Bibliográficos
Autores principales: Masuda, Yuji, Suzuki, Miki, Kawai, Hidehiko, Suzuki, Fumio, Kamiya, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273806/
https://www.ncbi.nlm.nih.gov/pubmed/21967848
http://dx.doi.org/10.1093/nar/gkr805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273806/
https://www.ncbi.nlm.nih.gov/pubmed/21967848
http://dx.doi.org/10.1093/nar/gkr805

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