Three critical hydrogen bonds determine the catalytic activity of the Diels–Alderase ribozyme

Compared to protein enzymes, our knowledge about how RNA accelerates chemical reactions is rather limited. The crystal structures of a ribozyme that catalyzes Diels–Alder reactions suggest a rich tertiary architecture responsible for catalysis. In this study, we systematically probe the relevance of...

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Detalles Bibliográficos
Autores principales: Kraut, Stefanie, Bebenroth, Dirk, Nierth, Alexander, Kobitski, Andrei Y., Nienhaus, G. Ulrich, Jäschke, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273808/
https://www.ncbi.nlm.nih.gov/pubmed/21976731
http://dx.doi.org/10.1093/nar/gkr812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273808/
https://www.ncbi.nlm.nih.gov/pubmed/21976731
http://dx.doi.org/10.1093/nar/gkr812

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