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Three critical hydrogen bonds determine the catalytic activity of the Diels–Alderase ribozyme
Compared to protein enzymes, our knowledge about how RNA accelerates chemical reactions is rather limited. The crystal structures of a ribozyme that catalyzes Diels–Alder reactions suggest a rich tertiary architecture responsible for catalysis. In this study, we systematically probe the relevance of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273808/ https://www.ncbi.nlm.nih.gov/pubmed/21976731 http://dx.doi.org/10.1093/nar/gkr812 |