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Robust nuclear lamina-based cell classification of aging and senescent cells

Changes in the shape of the nuclear lamina are exhibited in senescent cells, as well as in cells expressing mutations in lamina genes. To identify cells with defects in the nuclear lamina we developed an imaging method that quantifies the intensity and curvature of the nuclear lamina. We show that t...

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Detalles Bibliográficos
Autores principales: Righolt, Christiaan H., van 't Hoff, Merel L.R., Vermolen, Bart J., Young, Ian T., Raz, Vered
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273899/
https://www.ncbi.nlm.nih.gov/pubmed/22199022