Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling(1). In this study we report the presence of loss-of-function mutations and deletions of EZH2 and SUZ12 genes, encoding critical components of the Polycomb Rep...

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Detalles Bibliográficos
Autores principales: Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Van Vlierberghe, Pieter, Nedjic, Jelena, Trimarchi, Thomas, Flaherty, Maria Sol, Ferres-Marco, Dolors, da Ros, Vanina, Tang, Zuojian, Siegle, Jasmin, Asp, Patrik, Hadler, Michael, Rigo, Isaura, De Keersmaecker, Kim, Patel, Jay, Huynh, Tien, Utro, Filippo, Poglio, Sandrine, Samon, Jeremy B., Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M., Rabadan, Raul, Levine, Ross L., Brown, Stuart, Pflumio, Francoise, Dominguez, Maria, Ferrando, Adolfo, Aifantis, Iannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274628/
https://www.ncbi.nlm.nih.gov/pubmed/22237151
http://dx.doi.org/10.1038/nm.2651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274628/
https://www.ncbi.nlm.nih.gov/pubmed/22237151
http://dx.doi.org/10.1038/nm.2651

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