A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20

In addition to allelic mutations, cancers are known to harbor alterations in their chromatin landscape. Here, we show that genomic ablation of Smurf2, a HECT-domain E3 ubiquitin ligase, results in dysregulation of DNA damage response and genomic stability, culminating to increased susceptibility to...

Descripción completa

Detalles Bibliográficos
Autores principales: Blank, Michael, Tang, Yi, Yamashita, Motozo, Burkett, Sandra S., Cheng, Steven Y., Zhang, Ying E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274650/
https://www.ncbi.nlm.nih.gov/pubmed/22231558
http://dx.doi.org/10.1038/nm.2596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274650/
https://www.ncbi.nlm.nih.gov/pubmed/22231558
http://dx.doi.org/10.1038/nm.2596

Ejemplares similares