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A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20
In addition to allelic mutations, cancers are known to harbor alterations in their chromatin landscape. Here, we show that genomic ablation of Smurf2, a HECT-domain E3 ubiquitin ligase, results in dysregulation of DNA damage response and genomic stability, culminating to increased susceptibility to...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274650/ https://www.ncbi.nlm.nih.gov/pubmed/22231558 http://dx.doi.org/10.1038/nm.2596 |