Mutations in Human αA-Crystallin/sHSP Affect Subunit Exchange Interaction with αB-Crystallin

BACKGROUND: Mutation in αA-crystallin contributes to the development of congenital cataract in humans. Heterooligomerization of αA-crystallin and αB-crystallin is essential for maintaining transparency in the eye lens. The effect of congenital cataract causing mutants of αA-crystallin on subunit exc...

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Detalles Bibliográficos
Autores principales: Raju, Ilangovan, Oonthonpan, Lalita, Abraham, Edathara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275625/
https://www.ncbi.nlm.nih.gov/pubmed/22347476
http://dx.doi.org/10.1371/journal.pone.0031421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275625/
https://www.ncbi.nlm.nih.gov/pubmed/22347476
http://dx.doi.org/10.1371/journal.pone.0031421

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