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Mutations in Human αA-Crystallin/sHSP Affect Subunit Exchange Interaction with αB-Crystallin
BACKGROUND: Mutation in αA-crystallin contributes to the development of congenital cataract in humans. Heterooligomerization of αA-crystallin and αB-crystallin is essential for maintaining transparency in the eye lens. The effect of congenital cataract causing mutants of αA-crystallin on subunit exc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275625/ https://www.ncbi.nlm.nih.gov/pubmed/22347476 http://dx.doi.org/10.1371/journal.pone.0031421 |