Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

Women with type 2 diabetes (T2DM) are at greater risk of developing and dying from breast cancer than women without T2DM. Insulin resistance and hyperinsulinemia underlie the pathogenesis of T2DM. In the MKR mouse model of insulin resistance, we have previously shown increased activation of the phos...

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Detalles Bibliográficos
Autores principales: Gallagher, Emily Jane, Fierz, Yvonne, Vijayakumar, Archana, Haddad, Nadine, Yakar, Shoshana, LeRoith, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275680/
https://www.ncbi.nlm.nih.gov/pubmed/22037215
http://dx.doi.org/10.1038/onc.2011.495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275680/
https://www.ncbi.nlm.nih.gov/pubmed/22037215
http://dx.doi.org/10.1038/onc.2011.495

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