Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology

Mutations in the postsynaptic scaffolding gene SHANK2 have recently been identified in individuals with autism spectrum disorder (ASD) and intellectual disability. However, the cellular and physiological consequences of these mutations in neurons remain unknown. We have analyzed the functional impac...

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Detalles Bibliográficos
Autores principales: Berkel, Simone, Tang, Wannan, Treviño, Mario, Vogt, Miriam, Obenhaus, Horst Andreas, Gass, Peter, Scherer, Stephen Wayne, Sprengel, Rolf, Schratt, Gerhard, Rappold, Gudrun Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276277/
https://www.ncbi.nlm.nih.gov/pubmed/21994763
http://dx.doi.org/10.1093/hmg/ddr470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276277/
https://www.ncbi.nlm.nih.gov/pubmed/21994763
http://dx.doi.org/10.1093/hmg/ddr470

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