The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils

A number of amyloidogenic variants of apoA-I have been discovered but most have not been analyzed. Previously, we showed that the G26R mutation of apoA-I leads to increased β-strand structure, increased N-terminal protease susceptibility, and increased fibril formation after several days of incubati...

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Detalles Bibliográficos
Autores principales: Petrlova, Jitka, Duong, Trang, Cochran, Megan C., Axelsson, Annika, Mörgelin, Matthias, Roberts, Linda M., Lagerstedt, Jens O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276462/
https://www.ncbi.nlm.nih.gov/pubmed/22184756
http://dx.doi.org/10.1194/jlr.M020883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276462/
https://www.ncbi.nlm.nih.gov/pubmed/22184756
http://dx.doi.org/10.1194/jlr.M020883

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