Cure of ADPKD by Selection for Spontaneous Genetic Repair Events in Pkd1-Mutated iPS Cells

Induced pluripotent stem cells (iPSCs) generated by epigenetic reprogramming of personal somatic cells have limited therapeutic capacity for patients suffering from genetic disorders. Here we demonstrate restoration of a genomic mutation heterozygous for Pkd1 (polycystic kidney disease 1) deletion (...

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Detalles Bibliográficos
Autores principales: Cheng, Li-Tao, Nagata, Shogo, Hirano, Kunio, Yamaguchi, Shinpei, Horie, Shigeo, Ainscough, Justin, Tada, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276537/
https://www.ncbi.nlm.nih.gov/pubmed/22347511
http://dx.doi.org/10.1371/journal.pone.0032018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276537/
https://www.ncbi.nlm.nih.gov/pubmed/22347511
http://dx.doi.org/10.1371/journal.pone.0032018

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