Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo

Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report tha...

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Detalles Bibliográficos
Autores principales: Marcinowski, Lisa, Tanguy, Mélanie, Krmpotic, Astrid, Rädle, Bernd, Lisnić, Vanda J., Tuddenham, Lee, Chane-Woon-Ming, Béatrice, Ruzsics, Zsolt, Erhard, Florian, Benkartek, Corinna, Babic, Marina, Zimmer, Ralf, Trgovcich, Joanne, Koszinowski, Ulrich H., Jonjic, Stipan, Pfeffer, Sébastien, Dölken, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276556/
https://www.ncbi.nlm.nih.gov/pubmed/22346748
http://dx.doi.org/10.1371/journal.ppat.1002510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276556/
https://www.ncbi.nlm.nih.gov/pubmed/22346748
http://dx.doi.org/10.1371/journal.ppat.1002510

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