Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

Antibody diversification necessitates targeted mutation of regions within the immunoglobulin locus by activation-induced cytidine deaminase (AID). While AID is known to act on single-stranded DNA (ssDNA), the source, structure, and distribution of these substrates in vivo remain unclear. Using the t...

Descripción completa

Detalles Bibliográficos
Autores principales: Parsa, Jahan-Yar, Ramachandran, Shaliny, Zaheen, Ahmad, Nepal, Rajeev M., Kapelnikov, Anat, Belcheva, Antoaneta, Berru, Maribel, Ronai, Diana, Martin, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276561/
https://www.ncbi.nlm.nih.gov/pubmed/22346767
http://dx.doi.org/10.1371/journal.pgen.1002518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276561/
https://www.ncbi.nlm.nih.gov/pubmed/22346767
http://dx.doi.org/10.1371/journal.pgen.1002518

Ejemplares similares