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Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

Antibody diversification necessitates targeted mutation of regions within the immunoglobulin locus by activation-induced cytidine deaminase (AID). While AID is known to act on single-stranded DNA (ssDNA), the source, structure, and distribution of these substrates in vivo remain unclear. Using the t...

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Detalles Bibliográficos
Autores principales:	Parsa, Jahan-Yar, Ramachandran, Shaliny, Zaheen, Ahmad, Nepal, Rajeev M., Kapelnikov, Anat, Belcheva, Antoaneta, Berru, Maribel, Ronai, Diana, Martin, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276561/ https://www.ncbi.nlm.nih.gov/pubmed/22346767 http://dx.doi.org/10.1371/journal.pgen.1002518

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