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An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

BACKGROUND: In drug discovery, a positive Ames test for bacterial mutation presents a significant hurdle to advancing a drug to clinical trials. In a previous paper, we discussed success in predicting the genotoxicity of reagent-sized aryl-amines (ArNH(2)), a structure frequently found in marketed d...

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Detalles Bibliográficos
Autores principales: McCarren, Patrick, Springer, Clayton, Whitehead, Lewis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277490/
https://www.ncbi.nlm.nih.gov/pubmed/22107807
http://dx.doi.org/10.1186/1758-2946-3-51