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An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential
BACKGROUND: In drug discovery, a positive Ames test for bacterial mutation presents a significant hurdle to advancing a drug to clinical trials. In a previous paper, we discussed success in predicting the genotoxicity of reagent-sized aryl-amines (ArNH(2)), a structure frequently found in marketed d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277490/ https://www.ncbi.nlm.nih.gov/pubmed/22107807 http://dx.doi.org/10.1186/1758-2946-3-51 |