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Structure and Kinetic Stability of the p63 Tetramerization Domain
The p53 family of transcription factors—comprising p53, p63 and p73—plays an important role in tumor prevention and development. Essential to their function is the formation of tetramers, allowing cooperative binding to their DNA response elements. We solved crystal structures of the human p63 tetra...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277882/ https://www.ncbi.nlm.nih.gov/pubmed/22100306 http://dx.doi.org/10.1016/j.jmb.2011.11.007 |