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Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter()

AIMS: Multiple sclerosis (MS) leaves a signature on the phosphorylation and thus proton binding capacity of axonal neurofilament (Nf) proteins. The proton binding capacity in a tissue is the major determinant for exchange between bound and free protons and thus the magnetisation transfer ratio (MTR)...

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Detalles Bibliográficos
Autores principales: Petzold, A., Tozer, D.J., Schmierer, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277890/
https://www.ncbi.nlm.nih.gov/pubmed/21958956
http://dx.doi.org/10.1016/j.expneurol.2011.09.011