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Synthesis, characterization, and in vivo efficacy evaluation of PGG–docetaxel conjugate for potential cancer chemotherapy

AIM: This work is intended to develop and evaluate a biopolymeric poly(L-γ-glutamylglutamine) (PGG)–docetaxel (DTX) conjugate that can spontaneously self-assemble in aqueous solutions to become nanoparticles. METHODS: DTX was covalently attached to hydrophilic PGG by direct esterification, and the c...

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Detalles Bibliográficos
Autores principales:	Yang, Danbo, Van, Sang, Shu, Yingyi, Liu, Xiaoqing, Ge, Yangfeng, Jiang, Xinguo, Jin, Yi, Yu, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278226/ https://www.ncbi.nlm.nih.gov/pubmed/22334784 http://dx.doi.org/10.2147/IJN.S26842

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