Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+ )mice

BACKGROUND: The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and...

Descripción completa

Detalles Bibliográficos
Autores principales: Brudvik, Kristoffer W, Paulsen, Jan E, Aandahl, Einar M, Roald, Borghild, Taskén, Kjetil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278393/
https://www.ncbi.nlm.nih.gov/pubmed/22168384
http://dx.doi.org/10.1186/1476-4598-10-149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278393/
https://www.ncbi.nlm.nih.gov/pubmed/22168384
http://dx.doi.org/10.1186/1476-4598-10-149

Ejemplares similares