Cargando…

Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+ )mice

BACKGROUND: The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brudvik, Kristoffer W, Paulsen, Jan E, Aandahl, Einar M, Roald, Borghild, Taskén, Kjetil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278393/ https://www.ncbi.nlm.nih.gov/pubmed/22168384 http://dx.doi.org/10.1186/1476-4598-10-149

Ejemplares similares

Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival: A Scandinavian Single-Center Experience
por: Brudvik, Kristoffer Watten, et al.
Publicado: (2013)

Acarbose improved survival for Apc(+/Min) mice
por: Dodds, Sherry G., et al.
Publicado: (2020)

The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc(Min/+) mice
por: Ono, Junya, et al.
Publicado: (2017)

ERK activation drives intestinal tumorigenesis in Apc(min/)(+) mice
por: Lee, Sung Hee, et al.
Publicado: (2010)

Metabolomics of Apc( Min/+ ) mice genetically susceptible to intestinal cancer
por: Dazard, Jean-Eudes J, et al.
Publicado: (2014)

OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice
por: Yang, Y R, et al.
Publicado: (2014)

Intestinal Peyer’s patches prevent tumorigenesis in Apc(Min/+) mice
por: Fujimoto, Kyoko, et al.
Publicado: (2015)

Lactonic Sophorolipids Increase Tumor Burden in Apc(min+/-) Mice
por: Callaghan, Breedge, et al.
Publicado: (2016)

Platelet status in cancer cachexia progression in Apc(Min/+) mice
por: Cunningham, Patrice, et al.
Publicado: (2023)

Nuclear translocation of beta-catenin in colorectal cancer
por: Kobayashi, M, et al.
Publicado: (2000)

Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 Apc(Min)(/+) mice
por: Yanagihara, Hiromi, et al.
Publicado: (2023)

The effect of exercise on IL-6-induced cachexia in the Apc(Min/+) mouse
por: Puppa, Melissa J., et al.
Publicado: (2011)

Therapeutic utility of aspirin in the Apc(Min/+) murine model of colon carcinogenesis
por: Reuter, Brian K, et al.
Publicado: (2002)

Chemopreventive effects of berberine on intestinal tumor development in Apc(min/+) mice
por: Cao, Hailong, et al.
Publicado: (2013)

Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice
por: Liu, W, et al.
Publicado: (2016)

Dietary Uridine Decreases Tumorigenesis in the Apc(Min/+) Model of Intestinal Cancer
por: Field, Martha S, et al.
Publicado: (2018)

Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound
por: Fatehullah, A., et al.
Publicado: (2016)

Chemopreventive effect of 4′-hydroxychalcone on intestinal tumorigenesis in Apc(Min) mice
por: Chen, Qing, et al.
Publicado: (2021)

Transition state analogue of MTAP extends lifespan of APC(Min/+) mice
por: Firestone, Ross S., et al.
Publicado: (2021)

Chemopreventive effect of 4′-hydroxychalcone on intestinal tumorigenesis in Apc(Min) mice
por: Chen, Qing, et al.
Publicado: (2021)

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice
por: Caldwell, Christine M., et al.
Publicado: (2007)

Thymoquinone attenuates tumor growth in Apc(Min) mice by interference with Wnt-signaling
por: Lang, Michaela, et al.
Publicado: (2013)

Liver Inflammation and Metabolic Signaling in Apc(Min/+) Mice: The Role of Cachexia Progression
por: Narsale, Aditi A., et al.
Publicado: (2015)

Malic Enzyme 1 (ME1) is pro-oncogenic in Apc(Min/+) mice
por: Fernandes, Lorenzo M., et al.
Publicado: (2018)

Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APC(Min/+) mice
por: Li, Ye, et al.
Publicado: (2016)

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc(Min/+) mice
por: Zhong, Zhenyu, et al.
Publicado: (2017)

Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice
por: Ishigamori, Rikako, et al.
Publicado: (2017)

Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc(Min/+) mice
por: He, Zhengxiang, et al.
Publicado: (2017)

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the Apc(Min/+) model
por: Kawaguchi, Makiko, et al.
Publicado: (2016)

Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APC(Min/+) Mice
por: Datta, Kamal, et al.
Publicado: (2013)

Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin
por: Simcha, Inbal, et al.
Publicado: (1998)

Fas/CD95 Deficiency in Apc(Min/+) Mice Increases Intestinal Tumor Burden
por: Guillen-Ahlers, Hector, et al.
Publicado: (2010)

A method for non-invasive genotyping of APC(min/+ )mice using fecal samples
por: Symonds, Erin L, et al.
Publicado: (2012)

Characterization of the male Apc(Min/+) mouse as a hypogonadism model related to cancer cachexia
por: White, James P., et al.
Publicado: (2013)

Extrinsic intestinal denervation modulates tumor development in the small intestine of Apc(Min/+) mice
por: Liu, Verena, et al.
Publicado: (2015)

Intestinal tumor suppression in Apc(Min/+) mice by prostaglandin D(2) receptor PTGDR
por: Tippin, Brigette L, et al.
Publicado: (2014)

Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APC(MIN) Mouse Model
por: Asadi, Khalid, et al.
Publicado: (2017)

Inulin impacts tumorigenesis promotion by colibactin-producing Escherichia coli in Apc(Min/+) mice
por: Oliero, Manon, et al.
Publicado: (2023)

The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
por: Tonby, Kristian, et al.
Publicado: (2016)

APC: More than a beta (catenin) blocker
por: Leslie, Mitch
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_8j4sjbbidltep5m0fde7g7oacr