HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia

Cellular adaptation to hypoxic conditions mainly involves transcriptional changes in which hypoxia inducible factors (HIFs) play a critical role. Under hypoxic conditions, HIF protein is stabilized due to inhibition of the activity of prolyl hydroxylases (EGLNs). Because the reaction carried out by...

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Detalles Bibliográficos
Autores principales: Naranjo-Suarez, Salvador, Carlson, Bradley A., Tsuji, Petra A., Yoo, Min-Hyuk, Gladyshev, Vadim N., Hatfield, Dolph L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278416/
https://www.ncbi.nlm.nih.gov/pubmed/22348009
http://dx.doi.org/10.1371/journal.pone.0030470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278416/
https://www.ncbi.nlm.nih.gov/pubmed/22348009
http://dx.doi.org/10.1371/journal.pone.0030470

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