Cargando…

Defining a role for sphingosine kinase 1 in p53-dependent tumors

p53 is a crucial tumor suppressor that is mutated or deleted in a majority of cancers. Exactly how p53 prevents tumor progression has proved elusive for many years; however, this information is crucial to define targets for chemotherapeutic development that can effectively restore p53 function. Bioa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heffernan-Stroud, Linda A., Helke, Kristi L., Jenkins, Russell W., De Costa, Anna-Maria, Hannun, Yusuf A., Obeid, Lina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278571/ https://www.ncbi.nlm.nih.gov/pubmed/21765468 http://dx.doi.org/10.1038/onc.2011.302

Ejemplares similares

Transcriptional Regulation of Sphingosine Kinase 1
por: Bonica, Joseph, et al.
Publicado: (2020)

A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway
por: Carroll, Brittany L., et al.
Publicado: (2017)

Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer
por: Velazquez, Fabiola N., et al.
Publicado: (2021)

Distinct Roles for Hematopoietic and Extra-Hematopoietic Sphingosine Kinase-1 in Inflammatory Bowel Disease
por: Snider, Ashley J., et al.
Publicado: (2014)

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response
por: Xu, Ruijuan, et al.
Publicado: (2016)

1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase
por: Truman, Jean-Philip, et al.
Publicado: (2021)

CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles
por: Carroll, Brittany L., et al.
Publicado: (2016)

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides
por: Trayssac, Magali, et al.
Publicado: (2021)

P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment
por: Wada, Masayuki, et al.
Publicado: (2017)

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2
por: Xu, Ruijuan, et al.
Publicado: (2017)

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease
por: Kitatani, Kazuyuki, et al.
Publicado: (2015)

Inhibition of Sphingosine Kinase-2 in a Murine Model of Lupus Nephritis
por: Snider, Ashley J., et al.
Publicado: (2013)

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
por: Shamseddine, A A, et al.
Publicado: (2015)

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis
por: Ponnusamy, Suriyan, et al.
Publicado: (2012)

The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways
por: Ishay, Yuval, et al.
Publicado: (2021)

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn(2+)-dependent amidases
por: Yi, Jae Kyo, et al.
Publicado: (2022)

Drugging Sphingosine Kinases
por: Santos, Webster L., et al.
Publicado: (2014)

Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis
por: Zhang, Jiandi, et al.
Publicado: (1999)

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction
por: Hernández-Corbacho, María José, et al.
Publicado: (2011)

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells
por: Coant, Nicolas, et al.
Publicado: (2018)

Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis
por: Dai, Lan, et al.
Publicado: (2017)

An oncogenic role for sphingosine kinase 2
por: Neubauer, Heidi A., et al.
Publicado: (2016)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
por: Matula, Kasia, et al.
Publicado: (2015)

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
por: Bao, Yonghua, et al.
Publicado: (2017)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
por: Zeidan, Youssef H., et al.
Publicado: (2008)

Identification of Kinases Responsible for p53-Dependent Autophagy
por: Celano, Stephanie L., et al.
Publicado: (2019)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina
por: Porter, Hunter, et al.
Publicado: (2018)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
por: Cannavo, Alessandro, et al.
Publicado: (2017)

Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis
por: Wang, Shushu, et al.
Publicado: (2018)

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
por: Pitson, Stuart M., et al.
Publicado: (2005)

Sphingosine kinase 2 and multiple myeloma
por: Pyne, Nigel J., et al.
Publicado: (2017)

The Functional Role of Sphingosine Kinase 2
por: Diaz Escarcega, Rocio, et al.
Publicado: (2021)

Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells
por: Al-Rashed, Fatema, et al.
Publicado: (2021)

Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells
por: Ng, Mei Li, et al.
Publicado: (2018)

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1
por: Schwiebs, Anja, et al.
Publicado: (2016)

Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
por: Bhavanam, Naga P., et al.
Publicado: (2015)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
por: Dobierzewska, Aneta, et al.
Publicado: (2016)

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
por: Olivera, Ana, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_s2fmm36q1kinm7oa250avil2np