Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells

BACKGROUND: Farnesyltransferase inhibitor tipifarnib (R115777) has been used for treatment of hematological malignancies; however, its observed anticancer effect was limited. This prompted us to search for inhibitors that would show synergic, proapoptotic effect when combined with R115777. We decide...

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Detalles Bibliográficos
Autores principales: Krzykowska-Petitjean, Katarzyna, Małecki, Jędrzej, Bentke, Anna, Ostrowska, Barbara, Laidler, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278622/
https://www.ncbi.nlm.nih.gov/pubmed/22209975
http://dx.doi.org/10.1007/s00432-011-1131-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278622/
https://www.ncbi.nlm.nih.gov/pubmed/22209975
http://dx.doi.org/10.1007/s00432-011-1131-9

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