Cargando…

Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells

BACKGROUND: Farnesyltransferase inhibitor tipifarnib (R115777) has been used for treatment of hematological malignancies; however, its observed anticancer effect was limited. This prompted us to search for inhibitors that would show synergic, proapoptotic effect when combined with R115777. We decide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krzykowska-Petitjean, Katarzyna, Małecki, Jędrzej, Bentke, Anna, Ostrowska, Barbara, Laidler, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278622/ https://www.ncbi.nlm.nih.gov/pubmed/22209975 http://dx.doi.org/10.1007/s00432-011-1131-9

Ejemplares similares

Tipifarnib in the treatment of acute myeloid leukemia
por: Thomas, Xavier, et al.
Publicado: (2007)

Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia
por: Karp, Judith E, et al.
Publicado: (2008)

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension
por: Duluc, Lucie, et al.
Publicado: (2017)

Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis
por: Katragadda, Usha, et al.
Publicado: (2013)

Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations
por: Ho, Alan L., et al.
Publicado: (2021)

The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells
por: Wang, Qilin, et al.
Publicado: (2020)

Quantifying Heterogeneity According to Deformation of the U937 Monocytes and U937-Differentiated Macrophages Using 3D Carbon Dielectrophoresis in Microfluidics
por: Elitas, Meltem, et al.
Publicado: (2020)

Reactive Oxygen Species Imaging in U937 Cells
por: Prasad, Ankush, et al.
Publicado: (2020)

Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia
por: Raponi, Mitch, et al.
Publicado: (2004)

Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma
por: Alonso-Alonso, Ruth, et al.
Publicado: (2020)

Gallium-67 radiotoxicity in human U937 lymphoma cells.
por: Jonkhoff, A. R., et al.
Publicado: (1993)

Protective Effect of Glycomacropeptide on the Inflammatory Response of U937 Macrophages
por: Córdova-Dávalos, Laura Elena, et al.
Publicado: (2023)

α-bisabolol Is an Effective Proapoptotic Agent against BCR-ABL(+) Cells in Synergism with Imatinib and Nilotinib
por: Bonifacio, Massimiliano, et al.
Publicado: (2012)

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
por: Powers, Marissa V, et al.
Publicado: (2013)

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
por: Hutcheson, Jack, et al.
Publicado: (2005)

Apoptotic Effect of Nigella sativa on Human Lymphoma U937 Cells
por: Arslan, Belkis Atasever, et al.
Publicado: (2017)

Linagliptin inhibits lipopolysaccharide-induced inflammation in human U937 monocytes
por: Yamadera, Shiho, et al.
Publicado: (2018)

Study of the interaction of the C-reactive protein monomer with the U937 monocyte
por: Zhao, Jing, et al.
Publicado: (2010)

Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease
por: Kmita, Luana C, et al.
Publicado: (2019)

Effects of alpha-mangostin on the expression of anti-inflammatory genes in U937 cells
por: Liu, Szu-Hsiu, et al.
Publicado: (2012)

Proteasome (Prosome) Subunit Variations during the Differentiation of Myeloid U937 Cells
por: Henry, Laurent, et al.
Publicado: (1997)

U937 variant cells as a model of apoptosis without cell disintegration
por: Stasiłojć, Grzegorz, et al.
Publicado: (2013)

Inhibition of Exosome Release Sensitizes U937 Cells to PEGylated Liposomal Doxorubicin
por: Hekmatirad, Shirin, et al.
Publicado: (2021)

Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
por: Patwardhan, Chaitanya A., et al.
Publicado: (2023)

Crack/cocaine users show more family problems than other substance users
por: Moura, Helena Ferreira, et al.
Publicado: (2014)

Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells.
por: Garcia, J E, et al.
Publicado: (2000)

Alterations in protein glycosylation in PMA-differentiated U-937 cells exposed to mineral particles.
por: Trabelsi, N, et al.
Publicado: (1997)

Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells
por: Baek, Young-Sook, et al.
Publicado: (2009)

Pro-death and pro-survival properties of ouabain in U937 lymphoma derived cells
por: Cuozzo, Francesca, et al.
Publicado: (2012)

In vitro studies of the toxic effects of silver nanoparticles on HeLa and U937 cells
por: Kaba, Said I, et al.
Publicado: (2015)

Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
por: Thiel, Cora S., et al.
Publicado: (2018)

Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
por: Choi, Jung‐Hye, et al.
Publicado: (2002)

Interaction of Some Asymmetrical Porphyrins with U937 Cell Membranes–In Vitro and In Silico Studies
por: Mihai, Dragos Paul, et al.
Publicado: (2023)

A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors
por: DING, NING, et al.
Publicado: (2014)

Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy
por: Liu, Xiaoming, et al.
Publicado: (2022)

Interleukin-6 Released from Fibroblasts Is Essential for Up-regulation of Matrix Metalloproteinase-1 Expression by U937 Macrophages in Coculture: CROSS-TALKING BETWEEN FIBROBLASTS AND U937 MACROPHAGES EXPOSED TO HIGH GLUCOSE
por: Sundararaj, Kamala P., et al.
Publicado: (2009)

Pandemic shows deep vulnerabilities
por: Anderson, Molly D.
Publicado: (2020)

Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability
por: MacKinnon, Ruth N., et al.
Publicado: (2020)

m(6)A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes
por: Kleinbielen, Tamara, et al.
Publicado: (2022)

Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate
Publicado: (1989)

Cannot write session to /tmp/vufind_sessions/sess_fdqu9ebl4s4gvtroiq9sdu3i1k