APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1

The Anaphase-Promoting Complex/Cyclosome (APC/C) initiates mitotic exit by ubiquitinating cell-cycle regulators such as cyclin B1 and securin. Lys48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradat...

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Detalles Bibliográficos
Autores principales: Dimova, Nevena V., Hathaway, Nathaniel A., Lee, Byung-Hoon, Kirkpatrick, Donald S., Berkowitz, Marie Lea, Gygi, Steven P., Finley, Daniel, King, Randall W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278798/
https://www.ncbi.nlm.nih.gov/pubmed/22286100
http://dx.doi.org/10.1038/ncb2425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278798/
https://www.ncbi.nlm.nih.gov/pubmed/22286100
http://dx.doi.org/10.1038/ncb2425

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