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APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1
The Anaphase-Promoting Complex/Cyclosome (APC/C) initiates mitotic exit by ubiquitinating cell-cycle regulators such as cyclin B1 and securin. Lys48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278798/ https://www.ncbi.nlm.nih.gov/pubmed/22286100 http://dx.doi.org/10.1038/ncb2425 |