Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

BACKGROUND: Miltefosine (MF) is the first oral compound used in the chemotherapy against leishmaniasis. Since the mechanism of action of this drug and the targets of MF in Leishmania are unclear, we generated in a step-by-step manner Leishmania major promastigote mutants highly resistant to MF. Two...

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Detalles Bibliográficos
Autores principales: Coelho, Adriano C., Boisvert, Sébastien, Mukherjee, Angana, Leprohon, Philippe, Corbeil, Jacques, Ouellette, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279362/
https://www.ncbi.nlm.nih.gov/pubmed/22348164
http://dx.doi.org/10.1371/journal.pntd.0001512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279362/
https://www.ncbi.nlm.nih.gov/pubmed/22348164
http://dx.doi.org/10.1371/journal.pntd.0001512

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