Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

Mitotic arrest induced by antimitotic drugs can cause apoptosis or p53-dependent cell cycle arrest. It can also cause DNA damage, but the relationship between these events has been unclear. Live, single-cell imaging in human cancer cells responding to an antimitotic kinesin-5 inhibitor and additiona...

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Detalles Bibliográficos
Autores principales: Orth, James D., Loewer, Alexander, Lahav, Galit, Mitchison, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279386/
https://www.ncbi.nlm.nih.gov/pubmed/22171325
http://dx.doi.org/10.1091/mbc.E11-09-0781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279386/
https://www.ncbi.nlm.nih.gov/pubmed/22171325
http://dx.doi.org/10.1091/mbc.E11-09-0781

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