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LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation

BACKGROUND: Skeletal muscle myoblast differentiation and fusion into multinucleate myotubes is associated with dramatic cytoskeletal changes. We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule stabilization blocks differentiation. Factors responsibl...

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Detalles Bibliográficos
Autores principales: Mian, Isma, Pierre-Louis, Willythssa Stéphie, Dole, Neha, Gilberti, Renée M., Dodge-Kafka, Kimberly, Tirnauer, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279410/
https://www.ncbi.nlm.nih.gov/pubmed/22348111
http://dx.doi.org/10.1371/journal.pone.0031583